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ژن مقاومت آنتیبیوتیکی
genes (ARGs) and can easily transfer host antibiotic resistance genes to pathogenic microbes.
The horizontal transfer of ARGs between and within gut commensal bacterial communities to opportunistic pathogens in the gut may promote the emergence of multidrug-resistant (MDR) nosocomial pathogens.
Hence, the main effects of gut microbiota from post-antibiotic dysbiosis are loss of taxonomic and functional diversity combined with reduced colonization resistance against invading pathogens, which may harbour the ARGs.
Metagenomic approach helps in understanding the human gut microbiome, including the abundance and diversity of bacterial genera/species, identifying novel genes, microbial networks, ARGs and verifying the functional dysbiosis.
Currently, high-throughput sequencing-based metagenomic analysis has been widely used in ARG surveys and comparative human gut-associated resistome.
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